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NCT06300593

Activity of Chronic Inflammation in PCOS

Evaluation of the Activity of Chronic Inflammation and Its Impact on Metabolic and Hormonal Parameters in Various PCOS Phenotypes
Jagiellonian University·ClinicalTrials.gov·diagnostic testRecruiting
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Study focus
Disease/Condition
Polycystic Ovary Syndrome
Drug/Device/Intervention
Measurement and comparison of leucocytosis and concentrations of C-reactive protein (CRP), interleukin-1 (IL-1), IL-6, IL-10, Tumor Necrosis Factor (TNF-alpha) in PCOS phenotypes A, B, C and D
Study type
Observational
Intervention type
diagnostic test
Sponsor & location
Primary sponsor
Jagiellonian University
Location
Krakow, Poland
Timeline & enrollment
Phase
N/A
Start date
Jan 15, 2024
End date
Jun 30, 2024
Enrollment
80 participants
Primary outcome

Values of inflammation parameters - leukocytosis in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - C-reactive protein (CRP) in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-1 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-6 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - IL-10 in peripheral blood in the four PCOS phenotypes,Values of inflammation parameters - TNF-alpha in peripheral blood in the four PCOS phenotypes

Summary

Chronic inflammation in polycystic ovary syndrome (PCOS) may be the result of dysregulation
 of cytokine production (due to insulin resistance, excess visceral fat and
 hyperandrogenemia), i.e., overproduction of pro-inflammatory factors (e.g. TNF, IL-1, IL-6)
 in relation to anti-inflammatory ones (IL-10). This condition may be an important link
 between obesity and insulin resistance, which is crucial in the etiopathogenesis of the
 syndrome. However, it is not known whether it results from the tendency to accumulate adipose
 tissue or is a feature of the syndrome itself. There is no data indicating the relationship
 between chronic inflammation and the severity of metabolic disorders and the value of ovarian
 reserve in women with various PCOS phenotypes.

ICD-10 classifications
Polycystic ovarian syndromeOvarian dysfunction, unspecifiedOvarian dysfunctionOther ovarian dysfunctionNeoplasm of uncertain or unknown behaviour: Ovary
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06300593
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06300593 through Pure Global AI's free database. This phase not specified trial is sponsored by Jagiellonian University and is currently Recruiting. The study focuses on Polycystic Ovary Syndrome. Target enrollment is 80 participants.

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