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NCT06303830Completed

Bariatric Surgery and Cardiovascular Responses to Sodium Nitrate

Changes Induced by Bariatric Surgery in Cardiovascular Responses to Dietary Supplementation With Sodium Nitrate
University of Sao PauloClinicalTrials.govdietary supplement
Verified
Study focus
Disease/Condition
Hypertension
Drug/Device/Intervention
Sodium nitrate
Study type
Interventional
Intervention type
dietary supplement
Sponsor & location
Primary sponsor
University of Sao Paulo
Location
Ribeirão Preto, Brazil
Timeline & enrollment
Phase
N/A
Start date
Apr 16, 2019
End date
Oct 01, 2021
Enrollment
30 participants
Primary outcome

Assess changes in s-nitrosothiols

Summary

Inorganic nitrite and nitrate can be reduced to NO and NO-related species such as
 S-nitrosothiols via the nitrate-nitrite-NO pathway. This is due to the reduction of nitrate
 to nitrite by the action of bacteria in the mouth and the reduction of nitrite to NO
 depending on the acidic pH on the stomach or by enzymes with nitrite-reductase activity. The
 acidic environment of the stomach is very important to the formation of NO and
 S-nitrosothiols and several studies suggest that changes in gastric pH can affect this
 conversion. In this context, bariatric surgery, by altering the anatomy of the stomach and
 increasing gastric pH, can affect the nitrate-nitrite-NO pathway and change the
 antihypertensive and antioxidant effect of sodium nitrate.

ICD-10 classifications
Hypertensive diseasesRenovascular hypertensionSecondary hypertensionOther secondary hypertensionHypertensive heart disease
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06303830
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06303830 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Sao Paulo and is currently Completed. The study focuses on Hypertension. Target enrollment is 30 participants.

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