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NCT06304350Recruiting

Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma

A Single Arm, Single Center, Phase II Clinical Study of Pembrolizumab Combined With Preoperative Chemotherapy (Albumin Paclitaxel+Carboplatin) Neoadjuvant Therapy for Resectable Locally Advanced (Stage II/III) Esophageal Squamous Cell Carcinoma
Tongji UniversityPhase 2ClinicalTrials.govdrug
Verified
Study focus
Disease/Condition
Esophageal Cancer
Drug/Device/Intervention
Combination of pembrolizumab and platinum containing dual drugs
Study type
Interventional
Intervention type
drug
Sponsor & location
Primary sponsor
Tongji University
Location
Shanghai, China
Timeline & enrollment
Phase
Phase 2
Start date
Feb 17, 2024
End date
Dec 31, 2026
Enrollment
25 participants
Primary outcome

Pathological complete remission (pCR)

Summary

This study is a prospective, single center, open label, single arm clinical study. Select
 resectable locally advanced (cT3-4aN0M0, cT1-3N1-2M0, cII/III stage) esophageal cancer with
 pathological diagnosis of squamous cell carcinoma for inclusion, receive pembrolizumab
 combined with platinum containing dual drug (albumin paclitaxel+carboplatin) treatment for 2
 courses, and undergo surgery. After surgery, continue pembrolizumab immunotherapy. Using pCR
 as the main endpoint of the study

ICD-10 classifications
Carcinoma in situ: OesophagusMalignant neoplasm of oesophagusMalignant neoplasm: Middle third of oesophagusMalignant neoplasm: Overlapping lesion of oesophagusMalignant neoplasm: Upper third of oesophagus
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06304350
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06304350 through Pure Global AI's free database. This Phase 2 trial is sponsored by Tongji University and is currently Recruiting. The study focuses on Esophageal Cancer. Target enrollment is 25 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.