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NCT06320392Recruitment Completed

Implication of CCR4-NOT Complex Subunit 7 Expression in Natural Killer Cell Resistance in Metastatic Breast Cancer

CNOT7 Blood Level and Correlation to LAIR-1 in Metastatic vs Non-metastatic Breast Cancer Egyptian Patient's Cohort; a Case-Controlled Mechanistic Study
Ain Shams UniversityClinicalTrials.gov
Verified
Study focus
Disease/Condition
Metastatic Breast Cancer
Study type
Observational
Sponsor & location
Primary sponsor
Ain Shams University
Location
Cairo, Egypt
Timeline & enrollment
Phase
N/A
Start date
Jul 01, 2021
End date
Jun 01, 2024
Enrollment
90 participants
Primary outcome

Cytoplasmic mRNA deadenylase CNOT7 protein expression level in metastatic/advanced localized and non-metastatic BC sera using ELISA.,CNOT7 tissue expression level in BC tissue samples categorized as metastatic vs non-metastatic tumor alongside with adjacent non-tumor tissue margin using immunohistochemistry.,LAIR-1 protein expression level in BC patients peripheral blood samples using ELISA.

Summary

Being a mechanistic study, this work aims to figure out the role of the cytoplasmic mRNA
 deadenylase CNOT7 expressed protein on NK cell resistance in metastatic BC. In other words,
 to explore, whether, CNOT7 contributes to metastasis in Egyptian female metastatic BC
 patient's cohort, through NK cell resistance, or not.

ICD-10 classifications
Malignant neoplasm of breastMalignant neoplasm of breastMalignant neoplasm: Breast, unspecifiedMalignant neoplasm: Central portion of breastMalignant neoplasm: Overlapping lesion of breast
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06320392
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06320392 through Pure Global AI's free database. This phase not specified trial is sponsored by Ain Shams University and is currently Recruitment Completed. The study focuses on Metastatic Breast Cancer. Target enrollment is 90 participants.

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