NCT06323876

The Role of Quantitative CT and Radiomic Biomarkers for Precision Medicine in Pulmonary Fibrosis

Name: Clinical Trial NCT06323876
Creator: University of Virginia
Keywords: Idiopathic Pulmonary Fibrosis, HRCT, diagnostic test, clinical trial

University of Virginia·ClinicalTrials.gov·diagnostic testNot yet recruiting

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Study focus

Disease/Condition: Idiopathic Pulmonary Fibrosis
Drug/Device/Intervention: HRCT
Study type: Observational
Intervention type: diagnostic test

Sponsor & location

Primary sponsor: University of Virginia

Timeline & enrollment

Phase: N/A
Start date: May 01, 2024
End date: May 01, 2029
Enrollment: 160 participants

Primary outcome

Derivation of DTA in IPF only cases from the PFF-PR and its associations with disease severity and outcomes.,Determine whether known IPF-risk genetic variants are associated with DTA score.,Identify novel genetic variants that associate with DTA score progression.,Determine if DTA or any constituent radiomic features correlate with select plasma proteins.,Determine if DTA or any of constituent radiomic features correlate with transcriptomic,Determine the best combination of markers (DTA, proteins and transcriptome) for machine learning algorithms for AUC evaluation of ROCs on all 3 cohorts.

Summary

This observational study involves obtaining 2 chest CT scans; a historical baseline CT within ±1 year of enrollment into PRECISIONS, and a follow-up CT (either historical or prospective) 12 months ± 180 days after the baseline CT. Many IPF patients will have a CT scan every 12 months for disease monitoring and cancer screening. Participants will have the option to share historical CTs only or they can choose to have a research CT done for the follow-up scan, if a scan for clinical purposes is not available.

ICD-10 classifications

Other interstitial pulmonary diseases with fibrosisCystic fibrosis with pulmonary manifestationsCystic fibrosisGraphite fibrosis (of lung)Pulmonary heart disease, unspecified

Data source

Registry: ClinicalTrials.gov
Trial ID: NCT06323876
Type: Non-Device Trial

About this record

Access comprehensive clinical trial information for NCT06323876 through Pure Global AI's free database. This phase not specified trial is sponsored by University of Virginia and is currently Not yet recruiting. The study focuses on Idiopathic Pulmonary Fibrosis. Target enrollment is 160 participants.

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