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NCT06339398

To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study

Dose-response Effects of Physical Exercise Standardized Volume on Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study
Casa di Cura San Raffaele Cassino·ClinicalTrials.gov·behavioralEnrolling by invitation
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Study focus
Disease/Condition
Parkinson Disease
Drug/Device/Intervention
Aerobic exercise
Study type
Observational
Intervention type
behavioral
Sponsor & location
Primary sponsor
Casa di Cura San Raffaele Cassino
Location
Cassino, Italy
Timeline & enrollment
Phase
N/A
Start date
May 01, 2024
End date
May 31, 2028
Enrollment
30 participants
Primary outcome

Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL),Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL),Change in Brain-derived neurotrophic (BDNF) concentration assessed in peripheral blood samples (ng/mL)

Summary

This is a prospective, observational, cohort pilot study of standardize volume of aerobic
 exercise on changes in BDNF concentration at 4-weeks of exercise training among Parkinson
 disease patients.
 
 Thirty (N=30) participants will be consecutively enrolled and assigned to 2 groups: 1)
 Extensive Rehabilitation Group (exercise volume: 180 METs-min/week) or 2) Intensive
 Rehabilitation Group (exercise volume: 1350 METs-min/week).
 
 The primary objective is to evaluate the dose-response effects of two different
 rehabilitation settings, characterized by different workload (measured as energy
 expenditure), on blood BDNF levels.

ICD-10 classifications
Parkinson diseaseParkinsonism in diseases classified elsewhereDementia in Parkinson diseaseSecondary parkinsonismSecondary parkinsonism, unspecified
Data source
Registry
ClinicalTrials.gov
Trial ID
NCT06339398
Type
Non-Device Trial
About this record

Access comprehensive clinical trial information for NCT06339398 through Pure Global AI's free database. This phase not specified trial is sponsored by Casa di Cura San Raffaele Cassino and is currently Enrolling by invitation. The study focuses on Parkinson Disease. Target enrollment is 30 participants.

This page provides complete trial specifications, intervention details, outcomes, and location information. Pure Global AI offers free access to ClinicalTrials.gov data, helping medical device and pharmaceutical companies navigate clinical research efficiently.