Comparison of Nafamostat and Unfractionated Heparin in RRT for Sepsis Associated AKI

Platelet decline rate

The goal of this clinical trial is to compare the safety and efficacy of nafamostat mesylate
 (NM) and unfractionated heparin (UFH) in the process of renal replacement therapy (RRT) for
 patients suffering from sepsis associated acute kidney injury (SA-AKI). The main questions it
 aims to answer are:
 
 The impact of NM and UFH on platelet count in septic patients undergoing RRT treatment.
 
 The satisfaction with anticoagulation of NM and UFH in septic patients undergoing RRT
 treatment.
 
 The 28-day all-cause mortality rate of septic patients undergoing RRT treatment with NM and
 UFH.
 
 Researchers will use NM or UFH as anticoagulation during RRT in SA-AKI patients, assessing
 effects on platelet count, anticoagulation satisfaction, and mortality.
 
 Participants will receive NM or UFH as anticoagulation during RRT for a minimum of 7 days.
 Bleeding symptoms, platelet count and coagulation function will be monitored daily. Platelet
 changes during the 7-day treatment period and survival status at 28 days post-treatment will
 be recorded.