Immuno-based Profiling of knEe OA Patients to Predict reSponse to Regenerative Treatment

knee OA patients focusing on changes in Wnt and IL1-ß signalling and PTX3 expression

Osteoarthritis (OA) is a highly prevalent degenerative musculoskeletal disease and a major
 cause of chronic disability worldwide. Its multifactorial origin contributes to determine the
 heterogeneous phenotypes and one unmet need is the lack of biomarkers to predict the
 individual response. Platelet-rich-plasma (PRP) injection is a minimally invasive autologous
 blood-derived approach for which we plan to define specific knee profiles predictive of
 response. We will take advantage of a unique multidisciplinary approach aimed at analysing
 clinics, imaging, and biomarkers of associated with clinical response. We will focus on
 inflammatory (Wnt system, IL1 pathway, PTX3) and antioxidant (primarily, DPP3/Keap1/Nrf2)
 pathways. We foresee that our results will allow a better allocation of immunomodulatory and
 regenerative therapies for a personalized approach in knee OA thus maximising the
 effectiveness of the healthcare allocation.