Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome

Weight,Body mass index,Fat mass,Fat free mass,blood insulin level,systolic/diastolic Blood presure,Fasting blood glucose

Background. The prevalence of type 2 diabetes mellitus (T2D) in the world is constantly
 increasing. Treatment of T2D is complicated by arterial hypertension and obesity (metabolic
 syndrome - MS). Cardiovascular complications are the main cause of death in patients with MS.
 Objective weight loss improves clinical and laboratory parameters in patients with T2D and
 hypertension.
 
 Purpose: To study lifespan, glycemic and lipid metabolism, quality of life, and
 cost-effectiveness of pharmacologic, surgical, and dietetic weight loss methods in obese
 patients with MS at 24 weeks in a comparative clinical trial.
 
 Methods:
 
 1. st stage - Study design: An open pilot prospective clinical trial. The study included 71
 adult patients with T2D and hypertension for the Ramadan fast's (RF) weight loss.
 
 2. nd stage - Study design: A 24-week open label, prospective, multicenter, comparative
 clinical trial with the intention-to-treat analysis.
 
 Participants. Totally 150 adult patients with MS aged 35-65 years and with BMI≥27 kg/m2 for
 Asian will be included. They will be distributed in three comparative groups: drug treatment,
 surgery and diet.
 
 Primary endpoints: weight loss, fasting blood glucose, blood insulin level,
 systolic/diastolic BP.
 
 Secondary endpoints: blood lipids, heel bone mineral density (HBMD), and ejection fraction
 (EF).
 
 Expected results:
 
 A prospective multicenter clinical study will provide comparative results on life expectancy,
 glycemic and lipid metabolism, quality of life, cost-effectiveness of pharmacological,
 bariatric and dietary methods of weight loss in patients with obesity, T2D and hypertension.
 As a result of the research, the following will be published:
 
 1. at least three articles and/or reviews in peer-reviewed scientific publications indexed
 in the Science Citation Index Expanded of the Web Of Science database and/or having a
 Cite Score percentile in the Scopus of at least 50;
 
 2. at least 1 patent for an invention (including a positive decision on it).