Resistance Exercise and Creatine in Colorectal Cancer

Recruitment,Retention,Supplementation Adherence,Exercise Adherence

skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients.
 This condition arises from a combination of factors such as aging, inactivity, treatment side
 effects, malnutrition, tumor burden, and inflammation. Given this complexity, singular
 interventions may not be sufficient to address sarcopenia in this group.
 
 Creatine monohydrate, a compound vital for energy during exercise, has been extensively
 researched and proven safe and effective across various demographics, including older adults
 and clinical populations. Studies show that creatine enhances benefits from resistance
 training, indicating potential to counter muscle mass and function decline post-cancer
 treatment.
 
 This study aims to assess the feasibilty of combining creatine supplementation with
 resistance training versus resistance training alone in sarcopenic colorectal cancer
 survivors. A randomized controlled pilot trial will compare a 10-week program of resistance
 exercise plus creatine (EXSUPP) with resistance exercise alone (EXPLA), each with 20
 participants.